Scientifica IVM Single
A single axis motorised manipulator that enables precise, controlled positioning of pipettes and probes, including neuropixels probes and microelectrode arrays (MEAs). Ideal for a range of electrophysiology experiments, including field recordings and patch clamp, as well as microinjection experiments.
Compatible with stereotaxic frames, the long travel and ultra-smooth motion make this the perfect solution for in vivo experiments.
Maximises tissue health
Smooth probe insertion into the brain. Using the unique 'creeper' function to precisely control the movement of the manipulator, your probe can 'creep' to the desired position at a speed of your choice. This minimises tissue damage, reduces gliosis and increases the signal quality and data you receive from neurons.
Hit your precise target every time by programming the IVM to move to the exact brain region you are interested in, at a speed of your choice. The IVM has 20 nm resolution for absolute positioning. View the exact position of your probe using dedicated software and/or the Patch Pad display.
Perform long-term experiments
The high stability of the design ensures you can maintain position in the brain for reliable, long-term experiments.
High signal-to-noise ratio
The smooth approach, minimises tissue damage, maximises the signal-to-noise ratio and improves histology outcomes.
The low-noise electronics minimise disturbance to the sample and allows smaller signals to be detected.
Focus on your sample
The hands-free movement allows you to concentrate on the welfare of your sample during probe positioning. The risk of human error is reduced, which reduces wasted animals and time, increasing your experimental efficiency.
The continuous, smooth motion of the manipulator causes minimal vibrations compared to the stop-start motion of a manual manipulator. This improves accuracy and reduces damage, so you can draw reliable conclusions from your results.
Reach deep within your sample
The long 70mm range of travel means you can probe deep into your sample.
The IVM-1000 takes up less room, ideal if you are limited on space.
Operate via our ergonomically designed remote control options or through our specially designed LinLab software.
What is the unique 'creeper' function?
The creeper function in LinLab allows the movement of the manipulator to be programmed over a set distance at a pre-defined speed. This allows for smooth motion to the correct area of interest.
Alternatively, the step function can be used for faster, yet measured step movement to insert the electrode into the cell.
Design & Specifications
|Number of axes||
Number of axes1
Travel distance70 mm
Electronic resolution20 nm
|Minimum step size||
Minimum step size0.1 µm
Minimum speed1 µm per second
Maximum speed4 mm per second
Memory positions50 on control device (unlimited via LinLab)
SoftwareLinLab for Windows
Research Papers Expand
Abdi, A., Mallet, N., Mohamed, F., Sharott, A., Dodson, P., & Nakamura, K. et al. (2015). Prototypic and Arkypallidal Neurons in the Dopamine-Intact External Globus Pallidus. Journal Of Neuroscience, 35(17), 6667-6688. http://dx.doi.org/10.1523/jneu...
Bocian, R., Kazmierska, P., Kłos-Wojtczak, P., Kowalczyk, T., & Konopacki, J. (2015). Orexinergic theta rhythm in the rat hippocampal formation: In vitro and in vivo findings. Hippocampus, 25(11), 1393-1406. http://dx.doi.org/10.1002/hipo...
Boutin, R., Alsahafi, Z., & Pagliardini, S. (2016). Cholinergic modulation of the parafacial respiratory group. The Journal Of Physiology, 595(4), 1377-1392. http://dx.doi.org/10.1113/jp27...
Caban, B., Staszelis, A., Kazmierska, P., Kowalczyk, T., Konopacki, J. (2018). Postnatal Development of the Posterior Hypothalamic Theta Rhythm and Local Cell Discharges in Rat Brain Slices. Developmental Neurobiology, 78(11), 1049-1063. https://doi.org/10.1002/dneu.22628
Dai, J., Ozden, I., Brooks, D., Wagner, F., May, T., Agha, N., Brush, B., Borton, D., Nurmikko, A., Sheinberg, D. (2015). Modified toolbox for optogenetics in the nonhuman primate. Neurophotonics, 2(3), 031202. https://doi.org/10.1117/1.NPh.2.3.031202
Devonshire, I., Greenspon, C., & Hathway, G. (2015). Developmental alterations in noxious-evoked EEG activity recorded from rat primary somatosensory cortex. Neuroscience, 305, 343-350. http://dx.doi.org/10.1016/j.ne...
Devonshire, I., Kwok, C., Suvik, A., Haywood, A., Cooper, A., & Hathway, G. (2015). A quantification of the relationship between neuronal responses in the rat rostral ventromedial medulla and noxious stimulation-evoked withdrawal reflexes. European Journal Of Neuroscience, 42(1), 1726-1737. http://dx.doi.org/10.1111/ejn....
Dodson, P., Dreyer, J., Jennings, K., Syed, E., Wade-Martins, R., & Cragg, S. et al. (2016). Representation of spontaneous movement by dopaminergic neurons is cell-type selective and disrupted in parkinsonism. Proceedings Of The National Academy Of Sciences, 113(15), E2180-E2188. http://dx.doi.org/10.1073/pnas...
Dodson, P., Larvin, J., Duffell, J., Garas, F., Doig, N., & Kessaris, N. et al. (2015). Distinct Developmental Origins Manifest in the Specialized Encoding of Movement by Adult Neurons of the External Globus Pallidus. Neuron, 86(2), 501-513. http://dx.doi.org/10.1016/j.ne...
Doig, N., Magill, P., Apicella, P., Bolam, J., & Sharott, A. (2014). Cortical and Thalamic Excitation Mediate the Multiphasic Responses of Striatal Cholinergic Interneurons to Motivationally Salient Stimuli. Journal Of Neuroscience, 34(8), 3101-3117. http://dx.doi.org/10.1523/jneu...
Ford, M., Alexandrova, O., Cossell, L., Stange-Marten, A., Sinclair, J., & Kopp-Scheinpflug, C. et al. (2015). Tuning of Ranvier node and internode properties in myelinated axons to adjust action potential timing. Nature Communications, 6, 8073. http://dx.doi.org/10.1038/ncom...
Greenspon, C., Battell, E., Devonshire, I., Donaldson, L., Chapman, V., & Hathway, G. (2019). Lamina-specific population encoding of cutaneous signals in the spinal dorsal horn using multi-electrode arrays. The Journal of Physiology, 597(2), 377-397. https://physoc.onlinelibrary.w...
Kazmierska, P., & Konopacki, J. (2015). Development of theta rhythm in hippocampal formation slices perfused with 5-HT1A antagonist, (S)WAY 100135. Brain Research, 1625, 142-150. http://dx.doi.org/10.1016/j.br...
Kwok, C., Learoyd, A., Canet-Pons, J., Trang, T., & Fitzgerald, M. (2020). Spinal interleukin-6 contributes to central sensitisation and persistent pain hypersensitivity in a model of juvenile idiopathic arthritis. Elsevier. https://doi.org/10.1016/j.bbi.2020.08.004
Schweimer, J., Coullon, G., Betts, J., Burnet, P., Engle, S., & Brandon, N. et al. (2014). Increased burst-firing of ventral tegmental area dopaminergic neurons ind-amino acid oxidase knockout mice in vivo. European Journal Of Neuroscience, 40(7), 2999-3009. http://dx.doi.org/10.1111/ejn....
Sharott, A., Doig, N., Mallet, N., & Magill, P. (2012). Relationships between the Firing of Identified Striatal Interneurons and Spontaneous and Driven Cortical Activities In Vivo. Journal Of Neuroscience, 32(38), 13221-13236. http://dx.doi.org/10.1523/jneu...
Sollini, J., Chapuis, G A., Clopath, C., & Chadderton, C. (2018). ON-OFF receptive fields in auditory cortex diverge during development and contribute to directional sweep selectivity. Nature Communications, 2084(9). https://www.nature.com/article...
Stiles, L., Reynolds, J N., Napper, R., Zheng, Y., & Smith, P F. (2018). Single neuron activity and c-Fos expression in the rat striatum following electrical stimulation of the peripheral vestibular system. Physiological Reports, 6(13). https://physoc.onlinelibrary.w...
Viney, T J., Salib, M., Joshi, A., Unal, G., Berry, N., & Somogyi, P. Shared rhythmic subcortical GABAergic input to the entorhinal cortex and presubiculum. (2018). https://elifesciences.org/arti...
Zhang, C., Luo, W., Zhou, P., & Sun, T. (2016). Microinjection of acetylcholine into cerebellar fastigial nucleus induces blood depressor response in anesthetized rats. Neuroscience Letters, 629, 79-84. http://dx.doi.org/10.1016/j.ne...
Zhang, C., Sun, T., Zhou, P., Zhu, Q., & Zhang, L. (2015). Role of Muscarinic Acetylcholine Receptor-2 in the Cerebellar Cortex in Cardiovascular Modulation in Anaesthetized Rats. Neurochemical Research, 41(4), 804-812. http://dx.doi.org/10.1007/s110...
Dovetail Probe Holder (PH-1000)
Dovetail probe holder to fit bars/probes
Extended Right Angled Kopf Mount (IVM-650-00)
Allows the user to mount the IVM in one of four mounting positions on the Kopf or Stoelting manipulator.
LBM-7 Adjustable Mount (IVM-510-00)
This allows the approach axis of the LBM-7 to be removed, enabling the IVM be mounted in its place. It can then be rotated and locked in position at the correct angle.
LBM-7 Fixed Mount (IVM-505-00)
Allows the user to mount the IVM on the LBM-7 either to the approach axis stage or to the sliding carriage attached to the approach axis. If mounted on the approach axis stage it can only do so in the same axis as the stage. If mounted on the sliding bracket it can be mounted at 90º or in the same axis as the approach axis.
Extended Probe Holder
To hold capillary glass of 1-2 mm in diameter.
Right Angled Kopf Mount (IVM-520-00)
Allows the user to mount the IVM in a single mounting position on the Kopf or Stoelting manipulator.